Th17 Cells Exhibit Antitumor Effects in MDS Possibly through Augmenting Functions of CD8+ T Cells
Joint Authors
Shao, Zonghong
Wang, Huaquan
Fu, Rong
Li, Jing
Yue, Lanzhu
Liu, Chunyan
Tao, Jinglian
Qi, Weiwei
Wang, Yihao
Zhang, Wei
Liu, Hui
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Th17 cells are a newly found subset of distinct CD4+ Th effector cells’ family and are found to play an important role in cancers.
Myelodysplastic syndromes (MDS) are a common malignant hematological disease.
Here, we showed that both the percentage and the function of Th17 cells were elevated in low-risk MDS while being decreased in high-risk MDS.
Levels of upstream molecules of Th17 cells, IL-6 and IL-23, were higher in low-risk MDS but lower in high-risk MDS patients.
The abnormal percentage of Th17 cells was closely related to clinical parameters including karyotype, morphologic blast percentage of bone marrow, peripheral absolute neutrophil count, and hemoglobin concentration.
Furthermore, expression rates of perforin and granzyme B in BM CD3+CD8+ cells (cytotoxic T lymphocyte, CTL) positively correlated with levels of IL-17 but negatively correlated with BM blast percentage and could be significantly increased after stimulation with human recombinant IL-17 (rhIL-17).
Our results suggested that Th17 cells might play an antitumor effect in the pathogenesis of MDS through IL-17/CTL pathway.
American Psychological Association (APA)
Li, Jing& Yue, Lanzhu& Wang, Huaquan& Liu, Chunyan& Liu, Hui& Tao, Jinglian…[et al.]. 2016. Th17 Cells Exhibit Antitumor Effects in MDS Possibly through Augmenting Functions of CD8+ T Cells. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108919
Modern Language Association (MLA)
Li, Jing…[et al.]. Th17 Cells Exhibit Antitumor Effects in MDS Possibly through Augmenting Functions of CD8+ T Cells. Journal of Immunology Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1108919
American Medical Association (AMA)
Li, Jing& Yue, Lanzhu& Wang, Huaquan& Liu, Chunyan& Liu, Hui& Tao, Jinglian…[et al.]. Th17 Cells Exhibit Antitumor Effects in MDS Possibly through Augmenting Functions of CD8+ T Cells. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108919