New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy
Joint Authors
Guo, Qiujun
Liu, Rui
Hou, Wei
Hua, Bao Jin
He, Shulin
Xu, Xinyao
Yuan, Yuan
Jin, Zhichao
Xu, Tao
Wei, Huamin
Chen, Shuntai
Shi, Zhan
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The majority of basic and clinical studies have shown a protumor function of tumor-associated macrophages (TAMs), which represent a large proportion of matrix cells.
TAMs promote tumorigenesis, and their number is related to the malignancy degree and poor prognosis of many kinds of tumors.
Macrophage plasticity makes it possible to change the tumor microenvironment and remodel antitumor immunity during cancer immunotherapy.
Increasing numbers of studies have revealed the effects of TAMs on the tumor microenvironment, for example, via promotion of tumor growth and tumorigenesis and through an increase in the number of cancer stem cells or via facilitation of angiogenesis, lymphangiogenesis, and metastasis.
Investigators also proposed tumor-immunological treatments targeting TAMs by inhibiting TAM recruitment and differentiation, by regulating TAM polarization, and by blocking factors and pathways associated with the protumor function of TAMs.
This comprehensive review presents recent research on TAMs in relation to prediction of poor outcomes, remodeling of the tumor immune microenvironment, and immunological targeted therapies.
American Psychological Association (APA)
Guo, Qiujun& Jin, Zhichao& Yuan, Yuan& Liu, Rui& Xu, Tao& Wei, Huamin…[et al.]. 2016. New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108925
Modern Language Association (MLA)
Guo, Qiujun…[et al.]. New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108925
American Medical Association (AMA)
Guo, Qiujun& Jin, Zhichao& Yuan, Yuan& Liu, Rui& Xu, Tao& Wei, Huamin…[et al.]. New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108925