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Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis?
Joint Authors
Bertran, Thomas
Brachet, Patrick
Vareille-Delarbre, Marjolaine
Falenta, Julie
Dosgilbert, Annie
Vasson, Marie-Paule
Forestier, Christiane
Evrard, Bertrand
Tridon, Arlette
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections.
Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosystem.
In the genital mucosa, dendritic cells (DCs) sense bacteria of the microenvironment via receptors and then orchestrate the immune response by induction of different T cell subtypes.
We investigated the interactions between G.
vaginalis and human monocyte-derived DCs using a wide range of bacterial concentrations (multiplicity of infection from 0.01 to 100), and the effects of this pathogen on PHA-induced lymphocyte proliferation.
As observed by electron microscopy and cytometry, G.
vaginalis reduced the internalization ability of DCs by forming extracellular clusters and induced neither DC maturation, nor DC secretion of cytokines, except at the highest dose with a very early DC maturation state.
The same profile was observed on lymphocytes with significant increases of proliferation and cytokine secretion only at the highest bacterial concentration.
Our findings indicate that G.
vaginalis possesses slight immune-stimulating activities against DCs and T cells, reflecting thus a defective inflammatory response and giving rise to the atypical, non- or low-grade, inflammatory clinical disease profile.
American Psychological Association (APA)
Bertran, Thomas& Brachet, Patrick& Vareille-Delarbre, Marjolaine& Falenta, Julie& Dosgilbert, Annie& Vasson, Marie-Paule…[et al.]. 2016. Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis?. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108926
Modern Language Association (MLA)
Bertran, Thomas…[et al.]. Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis?. Journal of Immunology Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108926
American Medical Association (AMA)
Bertran, Thomas& Brachet, Patrick& Vareille-Delarbre, Marjolaine& Falenta, Julie& Dosgilbert, Annie& Vasson, Marie-Paule…[et al.]. Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis?. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108926