Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression
Joint Authors
Sharma, Divya Khandige
Bressler, Kamiko
Patel, Harshil
Balasingam, Nirujah
Thakor, Nehal
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Protein synthesis can be segmented into distinct phases comprising mRNA translation initiation, elongation, and termination.
Translation initiation is a highly regulated and rate-limiting step of protein synthesis that requires more than 12 eukaryotic initiation factors (eIFs).
Extensive evidence shows that the transcriptome and corresponding proteome do not invariably correlate with each other in a variety of contexts.
In particular, translation of mRNAs specific to angiogenesis, tumor development, and apoptosis is altered during physiological and pathophysiological stress conditions.
In cancer cells, the expression and functions of eIFs are hampered, resulting in the inhibition of global translation and enhancement of translation of subsets of mRNAs by alternative mechanisms.
A precise understanding of mechanisms involving eukaryotic initiation factors leading to differential protein expression can help us to design better strategies to diagnose and treat cancer.
The high spatial and temporal resolution of translation control can have an immediate effect on the microenvironment of the cell in comparison with changes in transcription.
The dysregulation of mRNA translation mechanisms is increasingly being exploited as a target to treat cancer.
In this review, we will focus on this context by describing both canonical and noncanonical roles of eIFs, which alter mRNA translation.
American Psychological Association (APA)
Sharma, Divya Khandige& Bressler, Kamiko& Patel, Harshil& Balasingam, Nirujah& Thakor, Nehal. 2016. Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression. Journal of Nucleic Acids،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1108985
Modern Language Association (MLA)
Sharma, Divya Khandige…[et al.]. Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression. Journal of Nucleic Acids No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1108985
American Medical Association (AMA)
Sharma, Divya Khandige& Bressler, Kamiko& Patel, Harshil& Balasingam, Nirujah& Thakor, Nehal. Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression. Journal of Nucleic Acids. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1108985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108985