Particle Size Dependent Photodynamic Anticancer Activity of Hematoporphyrin-Conjugated Fe3O4 Particles
Joint Authors
Choi, Kyong-Hoon
Park, Bong Joo
Nam, Ki Chang
Lee, Kyu-Dong
Kim, Jung Hyun
Jung, Jin-Seung
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nanomedicine, which involves the use of magnetic nanoparticles such as Fe3O4, has provided novel technical solutions for cancer diagnosis and treatment.
Most studies in nanomedicine have focused on the use of nanoparticles with magnetic resonance imaging and hyperthermia.
However, to achieve optimum anticancer effects, it is important to understand the physicochemical properties of magnetic nanoparticles and their interactions with biological entities.
In this study, we synthesized Fe3O4 particles of various sizes and conjugated them with hematoporphyrin (HP) molecules by using a simple surface-modification method.
HP molecules were covalently bound to the surface of Fe3O4 particles by a wet chemical process, resulting in Fe3O4@HPs particles that were uniform in size, were nontoxic, and exhibited strong anticancer effects on human prostate cancer (PC-3) and breast cancer (MDA-MB-231) cell lines.
The Fe3O4@HPs particles showed remarkable and efficient photodynamic anticancer activity, depending on their particle size.
These results indicate that all size of Fe3O4@HPs particles can be useful for photodynamic anticancer therapy, although the smaller size is better than the larger size and further studies will be needed to confirm the potential for clinical anticancer treatment.
American Psychological Association (APA)
Nam, Ki Chang& Choi, Kyong-Hoon& Lee, Kyu-Dong& Kim, Jung Hyun& Jung, Jin-Seung& Park, Bong Joo. 2016. Particle Size Dependent Photodynamic Anticancer Activity of Hematoporphyrin-Conjugated Fe3O4 Particles. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109000
Modern Language Association (MLA)
Nam, Ki Chang…[et al.]. Particle Size Dependent Photodynamic Anticancer Activity of Hematoporphyrin-Conjugated Fe3O4 Particles. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109000
American Medical Association (AMA)
Nam, Ki Chang& Choi, Kyong-Hoon& Lee, Kyu-Dong& Kim, Jung Hyun& Jung, Jin-Seung& Park, Bong Joo. Particle Size Dependent Photodynamic Anticancer Activity of Hematoporphyrin-Conjugated Fe3O4 Particles. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109000