Facile Method for Preparation of Silica Coated Monodisperse Superparamagnetic Microspheres

Abstract EN

This paper presents a facile method for preparation of silica coated monodisperse superparamagnetic microsphere.

Herein, monodisperse porous polystyrene-divinylbenzene microbeads were prepared by seeded emulsion polymerization and subsequently sulfonated with acetic acid/H2SO4.

The as-prepared sulfonated macroporous beads were magnetized in presence of Fe2+/Fe3+ under alkaline condition and were subjected to silica coating by sol-gel process, providing water compatibility, easily modifiable surface form, and chemical stability.

FE-SEM, TEM, FT-IR, and TGA were employed to characterize the silica coated monodisperse magnetic beads (~7.5 μm).

The proposed monodisperse magnetic beads can be used as mobile solid phase particles candidate for protein and DNA separation.