Gold Nanoplates as Cancer-Targeted Photothermal Actuators for Drug Delivery and Triggered Release
Joint Authors
Keynton, Robert S.
Patel, Dhruvin
Brann, Tyler
Chauhan, Rajat
James, Kurtis T.
Bates, Paula J.
Malik, Mohammad Tariq
O’Toole, Martin G.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The selective exposure of cancerous tissue to systemically delivered chemotherapeutic agents remains a major challenge facing cancer therapy.
To address this question, a near infrared responsive oligonucleotide-coated (AS1411, hairpin, or both) gold nanoplate loaded with doxorubicin is demonstrated to be nontoxic to cells without triggered release, while being acutely toxic to cells after 5 minutes of laser exposure to trigger DOX release.
Conjugation of oligonucleotides to the nanoplates is confirmed by an average increase in hydrodynamic diameter of 30.6 nm, an average blue shift of the plasmon resonance peak by 36 nm, and an average −10 mV shift in zeta potential of the particles.
DOX loading through intercalation into the hairpin DNA structure is confirmed through fluorescence measurements.
For both GNP-Hairpin and GNP-Hairpin-AS1411, ~60% of loaded DOX is released after the first 5 minutes of laser exposure ( λ = 817 nm), with complete release after two more 5-minute exposures.
Preliminary proof of concept is demonstrated in vitro using A549 and MDA-MB-231 cell lines as models for breast and lung cancer, respectively.
Exposure of cells to untriggered DOX-loaded conjugate with no laser exposure results in little to no toxicity, while laser-triggered release of DOX causes significant cell death.
American Psychological Association (APA)
Brann, Tyler& Patel, Dhruvin& Chauhan, Rajat& James, Kurtis T.& Bates, Paula J.& Malik, Mohammad Tariq…[et al.]. 2016. Gold Nanoplates as Cancer-Targeted Photothermal Actuators for Drug Delivery and Triggered Release. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109036
Modern Language Association (MLA)
Brann, Tyler…[et al.]. Gold Nanoplates as Cancer-Targeted Photothermal Actuators for Drug Delivery and Triggered Release. Journal of Nanomaterials No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1109036
American Medical Association (AMA)
Brann, Tyler& Patel, Dhruvin& Chauhan, Rajat& James, Kurtis T.& Bates, Paula J.& Malik, Mohammad Tariq…[et al.]. Gold Nanoplates as Cancer-Targeted Photothermal Actuators for Drug Delivery and Triggered Release. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109036