Confined Nystatin Polyenes in Nanopore Induce Biologic Ionic Selectivity
Joint Authors
Boukari, Khaoula
Paris, Guillaume
Gharbi, Tijani
Balme, Sébastien
Janot, Jean-Marc
Picaud, Fabien
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Antifungal polyenes such as nystatin (or amphotericin B) molecules play an important role in regulating ions permeability through membrane cell.
The creation of self-assembled nanopores into the fungal lipid membranes permits the leakage and the selectivity of ions (i.e., blockage of divalent cations) that cause the cell death.
These abilities are thus of first interest to promote new biomimetic membranes with improved ionic properties.
In the present work, we will use molecular dynamic simulations to interpret recent experimental data that showed the transfer of the nystatin action inside artificial nanopore in terms of ion permeability and selectivity.
We will demonstrate that nystatin polyenes can be stabilized in a hydrophobic carbon nanotube, even at high concentration.
The high potential interaction between the polyenes and the hydrophobic pore wall ensures the apparition of a hole inside the biomimetic nanopore that changes its intrinsic properties.
The probability ratios of cation versus anion show interesting reproducibility of experimental measurements and, to a certain extent, opened the way for transferring biological properties in synthetic membranes.
American Psychological Association (APA)
Boukari, Khaoula& Paris, Guillaume& Gharbi, Tijani& Balme, Sébastien& Janot, Jean-Marc& Picaud, Fabien. 2016. Confined Nystatin Polyenes in Nanopore Induce Biologic Ionic Selectivity. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109068
Modern Language Association (MLA)
Boukari, Khaoula…[et al.]. Confined Nystatin Polyenes in Nanopore Induce Biologic Ionic Selectivity. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109068
American Medical Association (AMA)
Boukari, Khaoula& Paris, Guillaume& Gharbi, Tijani& Balme, Sébastien& Janot, Jean-Marc& Picaud, Fabien. Confined Nystatin Polyenes in Nanopore Induce Biologic Ionic Selectivity. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109068