Improved Biocompatibility of Novel Biodegradable Scaffold Composed of Poly-L-lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery
Joint Authors
Gu, Dongsheng
Feng, Gaoke
Kang, Guanyang
Zheng, Xiaoxin
Bi, Yuying
Wang, Shihang
Fan, Jingyao
Xia, Jinxi
Wang, Zhimin
Huo, Zhicheng
Wang, Qun
Wu, Tim
Jiang, Xuejun
Gu, Weiwang
Xiao, Jianmin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Using poly-L-lactic acid for implantable biodegradable scaffold has potential biocompatibility issue due to its acidic degradation byproducts.
We have previously reported that the addition of amorphous calcium phosphate improved poly-L-lactic acid coating biocompatibility.
In the present study, poly-L-lactic acid and poly-L-lactic acid/amorphous calcium phosphate scaffolds were implanted in pig coronary arteries for 28 days.
At the follow-up angiographic evaluation, no case of stent thrombosis was observed, and the arteries that were stented with the copolymer scaffold had significantly less inflammation and nuclear factor-κB expression and a greater degree of reendothelialization.
The serum levels of vascular endothelial growth factor and nitric oxide, as well the expression of endothelial nitric oxide synthase and platelet-endothelial cell adhesion molecule-1, were also significantly higher.
In conclusion, the addition of amorphous calcium phosphate to biodegradable poly-L-lactic acid scaffold minimizes the inflammatory response, promotes the growth of endothelial cells, and accelerates the reendothelialization of the stented coronary arteries.
American Psychological Association (APA)
Gu, Dongsheng& Feng, Gaoke& Kang, Guanyang& Zheng, Xiaoxin& Bi, Yuying& Wang, Shihang…[et al.]. 2016. Improved Biocompatibility of Novel Biodegradable Scaffold Composed of Poly-L-lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109073
Modern Language Association (MLA)
Gu, Dongsheng…[et al.]. Improved Biocompatibility of Novel Biodegradable Scaffold Composed of Poly-L-lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery. Journal of Nanomaterials No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109073
American Medical Association (AMA)
Gu, Dongsheng& Feng, Gaoke& Kang, Guanyang& Zheng, Xiaoxin& Bi, Yuying& Wang, Shihang…[et al.]. Improved Biocompatibility of Novel Biodegradable Scaffold Composed of Poly-L-lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109073