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Preparation and Characterization of Modified Polyethyleneimine Magnetic Nanoparticles for Cancer Drug Delivery
Joint Authors
Arabi, Sedighe
Khoobi, Mehdi
Akbari Javar, Hamid
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Magnetic nanoparticles with polymeric coating have great significance in drug delivery purpose.
We intended to prepare a modified amphiphilic polymer with targeting susceptibility to reduce side effects to normal cells.
In this study polyethyleneimine (PEI) as a polycationic polymer reacted with sebacoyl chloride to make a new amphiphilic polymer and folic acid as a targeting agent to reduce cytotoxicity of polymer and increase specific entrance of nanoparticles to cancerous cells.
The obtained polymer (PEI-Sb-FA) was then coated on magnetic nanoparticles (MNPs) to stabilize them.
The core-shell nanoparticles were characterized by different methods such as scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM).
Curcumin was finally loaded on PEI-Sb-FA-MNPs and the release behavior was studied in different pH.
Curcumin loading of 28.2% was obtained and released drug in acidic pH = 4.5 was more than pH = 7.4, showing drug release sensitivity toward pH of media.
American Psychological Association (APA)
Arabi, Sedighe& Akbari Javar, Hamid& Khoobi, Mehdi. 2016. Preparation and Characterization of Modified Polyethyleneimine Magnetic Nanoparticles for Cancer Drug Delivery. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109075
Modern Language Association (MLA)
Arabi, Sedighe…[et al.]. Preparation and Characterization of Modified Polyethyleneimine Magnetic Nanoparticles for Cancer Drug Delivery. Journal of Nanomaterials No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109075
American Medical Association (AMA)
Arabi, Sedighe& Akbari Javar, Hamid& Khoobi, Mehdi. Preparation and Characterization of Modified Polyethyleneimine Magnetic Nanoparticles for Cancer Drug Delivery. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109075