Preparation and Characterization of Baicalein-Loaded Nanoliposomes for Antitumor Therapy
Joint Authors
Li, Kun
Zhang, Haizhao
Gao, Liming
Zhai, Yue
Shi, Ming
Li, Jian
Xiu, Chenlin
Cao, Junli
Cheng, Shaohui
Jiang, Li
Di, Hao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Baicalein (BAI) is a major constituent of Scutellaria baicalensis Georgi.
Previous studies showed that BAI had obvious effects on U14 cervical tumor-bearing mice model and HeLa cells.
However, the use of BAI is inconvenient and troublesome, due to its low oral bioavailability.
The aim of this study was to develop baicalein-loaded nanoliposomes (BAI-LP) to improve its bioavailability.
In this study, BAI-LP was prepared by thin film hydration method.
The average size, polydispersity index (PDI), zeta potential and encapsulation efficiency (EE) of the BAI-LP were 194.6 ± 2.08 nm, 0.17 ± 0.025 , - 30.73 ± 0.41 mV, and 44.3 ± 2.98 %, respectively.
Drug storage stability study showed no significant changes in these values after 4 weeks of storing at 4°C.
Additionally, Sulforhodamine B (SRB) experimental results indicated that the BAI-LP could achieve better anti-tumor effects than free BAI.
The results of the experiment demonstrated that BAI-LP had a better antitumor effect with a higher inhibition rate of 6 6.34 ± 15.33 % than free BAI with a inhibition rate of 41.89 ± 10.50 % by using U14 cervical tumor-bearing mice model.
In conclusion, the study suggested that BAI-LP would serve as a potent delivery vehicle for BAI in future cancer therapy.
American Psychological Association (APA)
Li, Kun& Zhang, Haizhao& Gao, Liming& Zhai, Yue& Shi, Ming& Li, Jian…[et al.]. 2016. Preparation and Characterization of Baicalein-Loaded Nanoliposomes for Antitumor Therapy. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109081
Modern Language Association (MLA)
Li, Kun…[et al.]. Preparation and Characterization of Baicalein-Loaded Nanoliposomes for Antitumor Therapy. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109081
American Medical Association (AMA)
Li, Kun& Zhang, Haizhao& Gao, Liming& Zhai, Yue& Shi, Ming& Li, Jian…[et al.]. Preparation and Characterization of Baicalein-Loaded Nanoliposomes for Antitumor Therapy. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109081