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Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery
Joint Authors
Render, Diane
Samuel, Temesgen
King, Howard
Vig, Madan
Babu, Ramapuram Jayachandra
Rangari, Vijaya K.
Jeelani, Shaik
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable alternatives to parenteral systems.
In the current work, eggshell-derived calcium carbonate (CaCO3) nanoparticles were used to develop enteric drug delivery system in the form of tablets.
CaCO3 nanoparticles were manufactured using top-down ball-milling method and characterized by X-ray diffractometry (XRD) and transmission electron microscopy (TEM) and loaded with 5-fluorouracil as a model drug.
Tablets with varying CaCO3 core and binder compositions were fabricated and coated with Eudragit S100 or Eudragit L100.
Suitability for enteric delivery of the tablets was tested by oral administration to rabbits and radiography.
Radiograph images showed that the tablet remained in the stomach of the rabbit for up to 3 hours.
Further modifications of these biomaterial-derived nanoparticles and the coatings will enable manufacturing of stable formulations for slow or controlled release of pharmaceuticals for enteric delivery.
American Psychological Association (APA)
Render, Diane& Samuel, Temesgen& King, Howard& Vig, Madan& Jeelani, Shaik& Babu, Ramapuram Jayachandra…[et al.]. 2016. Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109098
Modern Language Association (MLA)
Render, Diane…[et al.]. Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery. Journal of Nanomaterials No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109098
American Medical Association (AMA)
Render, Diane& Samuel, Temesgen& King, Howard& Vig, Madan& Jeelani, Shaik& Babu, Ramapuram Jayachandra…[et al.]. Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109098
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109098