Preparation, Characterization, and In Vitro and Vivo Antitumor Activity of Oridonin-Conjugated Multiwalled Carbon Nanotubes Functionalized with Carboxylic Group
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Carbon nanotubes have shown great potential in tumor therapy.
Oridonin (ORI) is a poorly water-soluble diterpenoid compound (C20H28O6) used in the treatment of esophageal and hepatic carcinoma for decades.
For the purpose of enhancing the antitumor potency and reducing cytotoxicity of ORI, multiwalled carbon nanotubes functionalized with carboxylic group (MWCNTs-COOH) were used as ORI carrier.
ORI was noncovalently encapsulated into (or onto) the functionalized carbon nanotubes (MWCNTs-ORI).
The obtained MWCNTs-ORI has been characterized.
The ORI loading efficiency in MWCNTs-COOH carrier was studied to be about 82.6% (w/w).
In vitro cytotoxicity assay on MWCNTs-ORI gave IC50 of 7.29 ± 0.5 μg/mL and ORI-F gave IC50 of 14.5 ± 1.4 μg/mL.
The antitumor effect studies in vivo showed that MWCNTs-ORI improved antitumor activity of ORI in comparison with ORI-F.
The tumor inhibition ratio for MWCNTs-ORI ( 1 .
68 × 1 0 - 2 g·Kg−1·d−1) was 86.4%, higher than that of ORI-F ( 1 .
68 × 1 0 - 2 g·Kg−1·d−1) which was 39.2%.
This can greatly improve the pharmaceutical efficiency and reduce potential side effects.
American Psychological Association (APA)
Wang, Chuanjin& Li, Wei. 2016. Preparation, Characterization, and In Vitro and Vivo Antitumor Activity of Oridonin-Conjugated Multiwalled Carbon Nanotubes Functionalized with Carboxylic Group. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109110
Modern Language Association (MLA)
Wang, Chuanjin& Li, Wei. Preparation, Characterization, and In Vitro and Vivo Antitumor Activity of Oridonin-Conjugated Multiwalled Carbon Nanotubes Functionalized with Carboxylic Group. Journal of Nanomaterials No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1109110
American Medical Association (AMA)
Wang, Chuanjin& Li, Wei. Preparation, Characterization, and In Vitro and Vivo Antitumor Activity of Oridonin-Conjugated Multiwalled Carbon Nanotubes Functionalized with Carboxylic Group. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109110