Delivery Efficiency of miR-21i-CPP-SWCNT and Its Inhibitory Effect on Fibrosis of the Renal Mesangial Cells
Joint Authors
Liu, Hong
Wang, Guobao
Yang, Yihong
Yu, Lei
Wang, Leyu
Wen, Zhengda
Hu, Xiaofang
Zou, Hequn
Qiu, Xiaozhong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
MicroRNA 21 (miR-21) was proved to cause renal fibrosis and the inhibition of miR-21 would improve the poor prognosis in renal cell carcinoma diseases.
The complementary oligonucleotide of mature miR-21 was considered to be an effective intracellular miR-21 inhibitor (miR-21i).
The directly effective delivery of miR-21i into fibrotic cell is a facile method for treatment of renal fibrosis.
Herein, the miR-21i-CPP-SWCNT delivery system, synthesized via single-walled carbon nanotube (SWCNT) and cell-penetrating peptide (CPP), was taken as a novel fibrosis-targeting therapeutic carrier.
The miR-21i and CPP firstly bind together via electrostatic forces, and subsequently miR-21i-CPP binds to the surface of SWCNTs via hydrophobic forces.
CPP could endow the delivery system with targeting property, while SWCNT would enhance its penetrating ability.
The exogenous miR-21i released from the designed miR-21i-CPP-SWCNTs had successfully inhibited the expression of fibrosis-related proteins in renal mesangial cells (RMCs).
We found that the expression of TGF-β1 proteins was more sensitive to miR-21i-CPP-SWCNT than the expression of α-SMA proteins.
American Psychological Association (APA)
Liu, Hong& Wang, Guobao& Yang, Yihong& Yu, Lei& Wang, Leyu& Wen, Zhengda…[et al.]. 2016. Delivery Efficiency of miR-21i-CPP-SWCNT and Its Inhibitory Effect on Fibrosis of the Renal Mesangial Cells. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109111
Modern Language Association (MLA)
Liu, Hong…[et al.]. Delivery Efficiency of miR-21i-CPP-SWCNT and Its Inhibitory Effect on Fibrosis of the Renal Mesangial Cells. Journal of Nanomaterials No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109111
American Medical Association (AMA)
Liu, Hong& Wang, Guobao& Yang, Yihong& Yu, Lei& Wang, Leyu& Wen, Zhengda…[et al.]. Delivery Efficiency of miR-21i-CPP-SWCNT and Its Inhibitory Effect on Fibrosis of the Renal Mesangial Cells. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109111