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Preparation and Evaluation of Solid-Self-Emulsifying Drug Delivery System Containing Paclitaxel for Lymphatic Delivery
Joint Authors
Cho, Hea-Young
Lee, Yong-Bok
Kang, Jun-Hyuk
Ngo, Lien
Tran, Phuong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Solid-self-emulsifying drug delivery system (S-SEDDS) of paclitaxel (Ptx) was developed by the spray drying method with the purpose of improving the low bioavailability (BA) of Ptx.
10% oil (ethyl oleate), 80% surfactant mixture (Tween 80 : Carbitol, 90 : 10, w/w), and 10% cosolvent (PEG 400) were chosen according to their solubilizing capacity.
The mean droplet size, zeta potential, and encapsulation efficiency of the prepared S-SEDDS were 16.9 ± 1.53 nm, 12.5 ± 1.66 mV, and 56.2 ± 8.1%, respectively.
In the S-SEDDS, Ptx presents in the form of molecular dispersion in the emulsions or is distributed in an amorphous state or crystalline with very small size.
The prepared S-SEDDS formulation showed 70 and 75% dissolution in 60 and 30 min in dissolution medium pH 1.2 and 6.8, respectively.
Significant increase (P≤0.05) in the peak concentration (Cmax), the area under the curve (AUC0–∞), and the lymphatic targeting efficiency of Ptx was observed after the oral administration of the Ptx-loaded S-SEDDS to rats (20 mg/kg as Ptx).
Our research suggests the prepared Ptx-loaded S-SEDDS can be a good candidate for the enhancement of BA and targeting drug delivery to the lymphatic system of Ptx.
American Psychological Association (APA)
Cho, Hea-Young& Kang, Jun-Hyuk& Ngo, Lien& Tran, Phuong& Lee, Yong-Bok. 2016. Preparation and Evaluation of Solid-Self-Emulsifying Drug Delivery System Containing Paclitaxel for Lymphatic Delivery. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1109122
Modern Language Association (MLA)
Cho, Hea-Young…[et al.]. Preparation and Evaluation of Solid-Self-Emulsifying Drug Delivery System Containing Paclitaxel for Lymphatic Delivery. Journal of Nanomaterials No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1109122
American Medical Association (AMA)
Cho, Hea-Young& Kang, Jun-Hyuk& Ngo, Lien& Tran, Phuong& Lee, Yong-Bok. Preparation and Evaluation of Solid-Self-Emulsifying Drug Delivery System Containing Paclitaxel for Lymphatic Delivery. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1109122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109122