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Acidic Tumor pH-Responsive Nanophotomedicine for Targeted Photodynamic Cancer Therapy
Joint Authors
Park, Wooram
Park, Sin-jung
Shin, Heejun
Na, Kun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
An acidic tumor pH-responsive nanophotomedicine (pH-NanoPM) for targeted photodynamic therapy (PDT) was demonstrated herein.
The pH-NanoPM was prepared with a size of ~110 nm by self-assembly of a pH-responsive polymeric photosensitizer (pH-PPS) consisting of pH-cleavable methoxypolyethylene glycol (pH-C-mPEG).
Because the pH-C-mPEG can be detached from the nanoparticles by hydrolysis of the benzoic-imine group at the pH of an acidic tumor (~6.5), the particle size and surface charge of the pH-NanoPM were changed along with the environmental pH condition.
After detachment of the pH-C-mPEG, the pH-NanoPM particles became positively charged (+18.67±1.95 mV) due to exposure of primary amine groups and decreased to a size of ~40 nm.
From in vitro cellular experiments with HeLa human cervical cancer cells, the pH-NanoPM exhibited enhanced cellular internalization at acidic tumor pH compared to normal pH, which led to a significant cancer cell killing effect.
These results suggest that this system has the potential to be used as a new class of nanophotomedicine for targeted photodynamic cancer therapy.
American Psychological Association (APA)
Park, Wooram& Park, Sin-jung& Shin, Heejun& Na, Kun. 2016. Acidic Tumor pH-Responsive Nanophotomedicine for Targeted Photodynamic Cancer Therapy. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109129
Modern Language Association (MLA)
Park, Wooram…[et al.]. Acidic Tumor pH-Responsive Nanophotomedicine for Targeted Photodynamic Cancer Therapy. Journal of Nanomaterials No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109129
American Medical Association (AMA)
Park, Wooram& Park, Sin-jung& Shin, Heejun& Na, Kun. Acidic Tumor pH-Responsive Nanophotomedicine for Targeted Photodynamic Cancer Therapy. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109129