Effect of an Albumin-Coated Mesoporous Silicon Nanoparticle Platform for Paclitaxel Delivery in Human Lung Cancer Cell Line A549
Joint Authors
Hou, Kezuo
Gao, Yu
Che, Xiaofang
Zheng, Chunlei
Qu, Xiujuan
Liu, Yunpeng
Zhu, Zhitu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Albumin-coated paclitaxel-mesoporous silicon nanoparticles (APMSN) were prepared to improve the anticancer effect in lung cancer by means of regulating the dissolution rate of paclitaxel (PTX).
PTX was absorbed into the mesoporous structure of mesoporous silicon nanoparticles (MSN), which was defined as PMSN.
PTX was proved to exist in an amorphous state in PMSN, which increased the dissolution rate of PTX.
Albumin was coated on the surface of MSN to form AMSN; AMSN and PTX were mixed to form APMSN in order to achieve sustained release of PTX.
Then, it was found that APMSN had more significant antiproliferate effects and induced more apoptotic proportion in comparison with PTX in A549 cells.
Furthermore, the absorption mechanism of APMSN into A549 cells was investigated.
Transmission electron microscopy (TEM) and laser scanning confocal microscopy (LSCM) showed that APMSN could cross the cell membrane and was taken into the cytoplasm quickly.
Taken together, our results demonstrate that AMSN carriers have potential as nanodrug delivery systems in the treatment of lung cancer.
American Psychological Association (APA)
Gao, Yu& Che, Xiaofang& Zheng, Chunlei& Hou, Kezuo& Qu, Xiujuan& Liu, Yunpeng…[et al.]. 2016. Effect of an Albumin-Coated Mesoporous Silicon Nanoparticle Platform for Paclitaxel Delivery in Human Lung Cancer Cell Line A549. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109154
Modern Language Association (MLA)
Gao, Yu…[et al.]. Effect of an Albumin-Coated Mesoporous Silicon Nanoparticle Platform for Paclitaxel Delivery in Human Lung Cancer Cell Line A549. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109154
American Medical Association (AMA)
Gao, Yu& Che, Xiaofang& Zheng, Chunlei& Hou, Kezuo& Qu, Xiujuan& Liu, Yunpeng…[et al.]. Effect of an Albumin-Coated Mesoporous Silicon Nanoparticle Platform for Paclitaxel Delivery in Human Lung Cancer Cell Line A549. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109154