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Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies
Joint Authors
Ding, Jianxun
Li, Mingqiang
Ma, Hongyun
Jiang, Weiqian
Cheng, Yilong
Sun, Shuo
Fu, Changfeng
Liu, Yi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Malignant spinal tumors, categorized into primary and metastatic ones, are one of the most serious diseases due to their high morbidity and mortality rates.
Common primary spinal tumors include chordoma, chondrosarcoma, osteosarcoma, Ewing’s sarcoma, and multiple myeloma.
Spinal malignancies are not only locally invasive and destructive to adjacent structures, such as bone, neural, and vascular structures, but also disruptive to distant organs (e.g., lung).
Current treatments for spinal malignancies, including wide resection, radiotherapy, and chemotherapy, have made significant progress like improving patients’ quality of life.
Among them, chemotherapy plays an important role, but its potential for clinical application is limited by severe side effects and drug resistance.
To ameliorate the current situation, various polymer nanoparticles have been developed as promising excipients to facilitate the effective treatment of spinal malignancies by utilizing their potent advantages, for example, targeting, stimuli response, and synergetic effect.
This review overviews the development of polymer nanoparticles for antineoplastic delivery in the treatment of spinal malignancies and discusses future prospects of polymer nanoparticle-based treatment methods.
American Psychological Association (APA)
Ma, Hongyun& Jiang, Weiqian& Ding, Jianxun& Li, Mingqiang& Cheng, Yilong& Sun, Shuo…[et al.]. 2016. Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1109195
Modern Language Association (MLA)
Ma, Hongyun…[et al.]. Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies. Journal of Nanomaterials No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1109195
American Medical Association (AMA)
Ma, Hongyun& Jiang, Weiqian& Ding, Jianxun& Li, Mingqiang& Cheng, Yilong& Sun, Shuo…[et al.]. Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1109195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109195