Studies on the Genotoxicity Behavior of Silver Nanoparticles in the Presence of Heavy Metal Cadmium Chloride in Mice
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Incredible rapid growth in the nanoparticles applications and development increases the daily human exposure to them but humans are exposed to many other pollutants in addition to nanoparticles that forced us to evaluate the effect of heavy metal cadmium chloride (CdCl2) coinjection on silver nanoparticles induced genotoxic risk in this study.
Mice were injected into the abdominal cavity with single dose of Ag nanoparticles (20, 41, and 82 mg/kg) or CdCl2 (1.5 mg/kg) either separately or together simultaneously and sacrificed 24 hours later.
CdCl2 cotreatment enhanced the induced dose-dependent sperm abnormality by Ag nanoparticles different doses as shown by the statistical significant decreases in both sperm concentration and motility and increases in the frequency of abnormal sperms and also potentiated the Ag nanoparticles induced chromosomal and DNA damage indicated by the statistical significant elevations in the frequencies of micronucleated polychromatic erythrocytes (MNPCEs) and DNA damage levels.
Moreover, statistical elevations in malondialdehyde level and reductions in catalase activity were observed after CdCl2 coinjection with Ag nanoparticles compared with Ag nanoparticles treated groups’ values.
Ag nanoparticles induced sperm abnormality, clastogenicity, and genotoxicity were potentiated by heavy metal cadmium coinjection that threatens the human life and increases silver nanoparticles genotoxic risks.
American Psychological Association (APA)
Mohamed, Hanan Ramadan Hamad. 2016. Studies on the Genotoxicity Behavior of Silver Nanoparticles in the Presence of Heavy Metal Cadmium Chloride in Mice. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1109225
Modern Language Association (MLA)
Mohamed, Hanan Ramadan Hamad. Studies on the Genotoxicity Behavior of Silver Nanoparticles in the Presence of Heavy Metal Cadmium Chloride in Mice. Journal of Nanomaterials No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1109225
American Medical Association (AMA)
Mohamed, Hanan Ramadan Hamad. Studies on the Genotoxicity Behavior of Silver Nanoparticles in the Presence of Heavy Metal Cadmium Chloride in Mice. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1109225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109225