Characterization of Inter- and Intramolecular Interactions of Amyloid Fibrils by AFM-Based Single-Molecule Force Spectroscopy
Joint Authors
Liu, Bo
Dong, Ming-Dong
Li, Yinli
Liang, Hao
Zhao, Huiling
Chen, Dong
Fuhs, Thomas
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-07
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Amyloids are fibrous protein aggregates defined by shared specific structural features.
Abnormal accumulation of amyloid in organs leads to amyloidosis, which results in various neurodegenerative diseases.
Atomic force microscopy (AFM) has proven to be an excellent tool investigating amyloids; it has been extensively utilized to characterize its morphology, assembly process, and mechanical properties.
This review summarizes studies which applied AFM to detect the inter- and intramolecular interactions of amyloid fibrils and classified the influencing factors of amyloid’s nanomechanics in detail.
The characteristics of amyloid fibrils driven by inter- and intramolecular interactions, including various morphologies of amyloid fibrils, self-assembly process, and the aggregating pathway, are described.
Successful examples where AFM provided abundant information about inter- and intramolecular interactions of amyloid fibrils in different environments are presented.
Direct force measurement of intra- or intermolecular interactions utilizing an AFM-based tool, single-molecular force spectroscopy (SMFS), is introduced.
Some mechanical information such as elasticity, adhesiveness, and strength was obtained by stretching amyloid fibrils.
This review helps researchers in understanding the mechanism of amyloidogenesis and exploring the properties of amyloid using AFM techniques.
American Psychological Association (APA)
Li, Yinli& Liang, Hao& Zhao, Huiling& Chen, Dong& Liu, Bo& Fuhs, Thomas…[et al.]. 2016. Characterization of Inter- and Intramolecular Interactions of Amyloid Fibrils by AFM-Based Single-Molecule Force Spectroscopy. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1109243
Modern Language Association (MLA)
Li, Yinli…[et al.]. Characterization of Inter- and Intramolecular Interactions of Amyloid Fibrils by AFM-Based Single-Molecule Force Spectroscopy. Journal of Nanomaterials No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1109243
American Medical Association (AMA)
Li, Yinli& Liang, Hao& Zhao, Huiling& Chen, Dong& Liu, Bo& Fuhs, Thomas…[et al.]. Characterization of Inter- and Intramolecular Interactions of Amyloid Fibrils by AFM-Based Single-Molecule Force Spectroscopy. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1109243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109243