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Nanomechanical Characterization of Amyloid Fibrils Using Single-Molecule Experiments and Computational Simulations
Joint Authors
Choi, Bumjoon
Kim, Taehee
Lee, Sang Woo
Eom, Kilho
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Amyloid fibrils have recently received much attention due to not only their important role in disease pathogenesis but also their excellent mechanical properties, which are comparable to those of mechanically strong protein materials such as spider silk.
This indicates the necessity of understanding fundamental principles providing insight into how amyloid fibrils exhibit the excellent mechanical properties, which may allow for developing biomimetic materials whose material (e.g., mechanical) properties can be controlled.
Here, we describe recent efforts to characterize the nanomechanical properties of amyloid fibrils using computational simulations (e.g., atomistic simulations) and single-molecule experiments (e.g., atomic force microscopy experiments).
This paper summarizes theoretical models, which are useful in analyzing the mechanical properties of amyloid fibrils based on simulations and experiments, such as continuum elastic (beam) model, elastic network model, and polymer statistical model.
In this paper, we suggest how the nanomechanical properties of amyloid fibrils can be characterized and determined using computational simulations and/or atomic force microscopy experiments coupled with the theoretical models.
American Psychological Association (APA)
Choi, Bumjoon& Kim, Taehee& Lee, Sang Woo& Eom, Kilho. 2016. Nanomechanical Characterization of Amyloid Fibrils Using Single-Molecule Experiments and Computational Simulations. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1109269
Modern Language Association (MLA)
Choi, Bumjoon…[et al.]. Nanomechanical Characterization of Amyloid Fibrils Using Single-Molecule Experiments and Computational Simulations. Journal of Nanomaterials No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1109269
American Medical Association (AMA)
Choi, Bumjoon& Kim, Taehee& Lee, Sang Woo& Eom, Kilho. Nanomechanical Characterization of Amyloid Fibrils Using Single-Molecule Experiments and Computational Simulations. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1109269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109269