Preparation, Characterization, and Antitumor Evaluation of Electrospun Resveratrol Loaded Nanofibers
Joint Authors
Zhou, Hui
Liu, Xiaoxing
Wu, Fenglei
Zhang, Junting
Wu, Zhen
Yin, Haitao
Shi, Hui
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Resveratrol has been reported as a potential antitumor agent for several years.
The possible application was greatly hampered by its poor solubility.
The current study reported the construction of electrospun Resveratrol loaded nanofibers with methoxypolyethylene glycol-poly(caprolactone) (mPEG-PCL) block copolymers as drug carriers.
Characterization studies showed the successful encapsulation of Rsv in the nanofibers with an in vitro sustained release pattern.
In vitro XTT assay suggested the superior cytotoxicity of Rsv-NFs with more apoptosis induction on cancer cells.
Cells that exposed to Rsv-NFs showed less clonogenic ability when compared to the equivalent dose of free Rsv.
In addition, the migration and invasion ability of cells were also significantly lower when treated with Rsv-NFs.
In the in vivo study, local implantation of Rsv-NFs greatly increased the growth inhibitory effect compared to free Rsv.
Therefore, results from the current study demonstrated a promising way to improve the antitumor effect of Rsv by nanofiber delivery.
American Psychological Association (APA)
Zhou, Hui& Liu, Xiaoxing& Wu, Fenglei& Zhang, Junting& Wu, Zhen& Yin, Haitao…[et al.]. 2016. Preparation, Characterization, and Antitumor Evaluation of Electrospun Resveratrol Loaded Nanofibers. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109270
Modern Language Association (MLA)
Zhou, Hui…[et al.]. Preparation, Characterization, and Antitumor Evaluation of Electrospun Resveratrol Loaded Nanofibers. Journal of Nanomaterials No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1109270
American Medical Association (AMA)
Zhou, Hui& Liu, Xiaoxing& Wu, Fenglei& Zhang, Junting& Wu, Zhen& Yin, Haitao…[et al.]. Preparation, Characterization, and Antitumor Evaluation of Electrospun Resveratrol Loaded Nanofibers. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109270