Spirulina-PCL Nanofiber Wound Dressing to Improve Cutaneous Wound Healing by Enhancing Antioxidative Mechanism
Joint Authors
Jung, Sang-Myung
Shin, Hwa Sung
Min, Seul Ki
Lee, Hoo Chul
Kwon, Yeo Seon
Jung, Moon Hee
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Skin regeneration is a complex process involving massive proliferation and alignment of cells, where there are obstacles to completion of regeneration, the main one being excessive generation of reactive oxygen species (ROS) from inflammation or infection.
Spirulina, blue-green algae that has antioxidant and anti-inflammatory activities, has been used to relieve such ROS stress.
In this study, Spirulina extract loaded PCL (Spirulina-PCL) nanofiber was evaluated as a cutaneous wound dressing in view of antioxidative mechanism.
In addition to increasing fibroblast viability, the Spirulina extract and its dressing modulated intra- and extracellular ROS by enhancing antioxidant mechanism of fibroblast under oxidative stress.
Finally, in vivo assays confirmed that Spirulina-PCL helps regenerate wounds and enhance regeneration.
Taken together, the results of this study indicate that Spirulina and nanofiber have the potential for application to cutaneous wound to facilitate skin regeneration.
American Psychological Association (APA)
Jung, Sang-Myung& Min, Seul Ki& Lee, Hoo Chul& Kwon, Yeo Seon& Jung, Moon Hee& Shin, Hwa Sung. 2016. Spirulina-PCL Nanofiber Wound Dressing to Improve Cutaneous Wound Healing by Enhancing Antioxidative Mechanism. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109291
Modern Language Association (MLA)
Jung, Sang-Myung…[et al.]. Spirulina-PCL Nanofiber Wound Dressing to Improve Cutaneous Wound Healing by Enhancing Antioxidative Mechanism. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109291
American Medical Association (AMA)
Jung, Sang-Myung& Min, Seul Ki& Lee, Hoo Chul& Kwon, Yeo Seon& Jung, Moon Hee& Shin, Hwa Sung. Spirulina-PCL Nanofiber Wound Dressing to Improve Cutaneous Wound Healing by Enhancing Antioxidative Mechanism. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109291