Electrospun ChitosanPolyethylene Oxide Nanofibrous Scaffolds with Potential Antibacterial Wound Dressing Applications
Joint Authors
Yuan, Tony T.
Jenkins, Phillip M.
DiGeorge Foushee, Ann Marie
Jockheck-Clark, Angela R.
Stahl, Jonathan M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Electrospinning is a simple and versatile technique for the fabrication of nonwoven fibrous materials for biomedical applications.
In the present study, chitosan (CS) and polyethylene oxide (PEO) nanofibrous scaffolds were successfully prepared using three different CS/PEO mass ratios and then evaluated for their physical, chemical, and biological characteristics.
Scaffold morphologies were observed by scanning electron microscopy, which showed decreasing fiber diameters with increasing CS content.
Higher CS concentrations also correlated with increased tensile strength and decreased elasticity of the scaffold.
Degradation studies demonstrated that PEO was solubilized from the scaffold within the first six hours, followed by CS.
This profile was unaffected by changes in the CS/PEO ratio or the pH of the media.
Only the 2 : 1 CS/PEO scaffold demonstrated superior inhibition of both growth and attachment of Staphylococcus aureus.
Finally, all scaffolds exhibited little impact on the proliferation of murine fibroblast monolayers.
These data demonstrate that the 2 : 1 CS/PEO scaffold is a promising candidate for wound dressing applications due to its excellent antibacterial characteristics and biocompatibility.
American Psychological Association (APA)
Yuan, Tony T.& Jenkins, Phillip M.& DiGeorge Foushee, Ann Marie& Jockheck-Clark, Angela R.& Stahl, Jonathan M.. 2016. Electrospun ChitosanPolyethylene Oxide Nanofibrous Scaffolds with Potential Antibacterial Wound Dressing Applications. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109296
Modern Language Association (MLA)
Yuan, Tony T.…[et al.]. Electrospun ChitosanPolyethylene Oxide Nanofibrous Scaffolds with Potential Antibacterial Wound Dressing Applications. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109296
American Medical Association (AMA)
Yuan, Tony T.& Jenkins, Phillip M.& DiGeorge Foushee, Ann Marie& Jockheck-Clark, Angela R.& Stahl, Jonathan M.. Electrospun ChitosanPolyethylene Oxide Nanofibrous Scaffolds with Potential Antibacterial Wound Dressing Applications. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109296