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Sensitivity Analysis for the Mechanical Properties of DNA Bundles
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In structural DNA nanotechnology, programming a three-dimensional shape into DNA bundles has been a primary design objective.
However, the mechanical properties of these DNA bundle structures are another important factor to be considered in the design process.
While the mechanics of the individual DNA double helix has been explored extensively and hence its properties are well known, the mechanical properties of structural motifs such as DNA junctions and strand breaks important to bundle mechanics have not been well characterized due to experimental limitations, rendering it difficult to predict the mechanical properties of DNA bundles.
Here, we investigate the effect of these structural motifs on the global bundle rigidities by performing sensitivity analysis on a six-helix DNA bundle structure using the finite element modeling approach.
Results reveal the primary structural features and their parametric values required to reproduce the experimental bundle rigidities.
American Psychological Association (APA)
Kim, Young-Joo& Kim, Do-Nyun. 2016. Sensitivity Analysis for the Mechanical Properties of DNA Bundles. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109300
Modern Language Association (MLA)
Kim, Young-Joo& Kim, Do-Nyun. Sensitivity Analysis for the Mechanical Properties of DNA Bundles. Journal of Nanomaterials No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1109300
American Medical Association (AMA)
Kim, Young-Joo& Kim, Do-Nyun. Sensitivity Analysis for the Mechanical Properties of DNA Bundles. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109300