Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells
Joint Authors
Wan, Jian-Bo
Xu, Yingqi
Li, Peng
Chen, Wen-Rong
Tsosie, Jonathan K.
Xie, Xi
He, Cheng-Wei
Chen, Mei-Wan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Curcumin, a natural chemical compound found in Curcuma longa, has been applied in multiple medicinal areas from antibiotic to antitumor treatment.
However, the chemical structure of curcumin results in poor stability, low solubility, and rapid degradation in vivo, hindering its clinical utilization.
To address these issues, we have developed a novel niosome system composed of nonionic surfactants: Span 80, Tween 80, and Poloxamer 188.
Curcumin was encapsulated in the niosomes with a high entrapment efficiency of 92.3 ± 0.4 %.
This system provided controlled release of curcumin, thereby improving its therapeutic capability.
Dynamic dialysis was conducted to evaluate the in vitro drug release of curcumin-niosomes.
Curcumin-niosomes exhibited enhanced cytotoxic activity and apoptotic rate against ovarian cancer A2780 cells compared with freely dispersed curcumin.
These results demonstrate that the curcumin-niosome system is a promising strategy for the delivery of curcumin and ovarian cancer therapy.
American Psychological Association (APA)
Xu, Yingqi& Chen, Wen-Rong& Tsosie, Jonathan K.& Xie, Xi& Li, Peng& Wan, Jian-Bo…[et al.]. 2016. Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109303
Modern Language Association (MLA)
Xu, Yingqi…[et al.]. Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109303
American Medical Association (AMA)
Xu, Yingqi& Chen, Wen-Rong& Tsosie, Jonathan K.& Xie, Xi& Li, Peng& Wan, Jian-Bo…[et al.]. Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109303