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Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles
Joint Authors
Tian, Ying
Wang, Shouju
Fei-Peng, Zhu
Guo-Tao, Chen
Ying, Liu
Yu-Xia, Tang
Jian-Dong, Wang
Chun-Yan, Wang
Xin, Wang
Jing, Sun
Zhao-Gang, Teng
Lu, Guang Ming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dual-modal imaging by combining magnetic resonance (MR) and near-infrared (NIR) fluorescence can integrate the advantages of high-resolution anatomical imaging with high sensitivity in vivo fluorescent imaging, which is expected to play a significant role in biomedical researches.
Here we report a dual-modality imaging probe (NIR/MR-MSNs) fabricated by conjugating NIR fluorescent heptamethine dyes (IR-808) and MR contrast agents (Gd-DTPA) within highly aminated mesoporous silica nanoparticles (MSNs-NH2).
The dual-modality imaging probes NIR/MR-MSNs possess a size of ca.
120 nm.
The NIR/MR-MSNs show not only near-infrared fluorescence imaging property with an emission peak at 794 nm, but also highly MR T 1 relaxivity of 14.54 mM−1 s−1, which is three times more than Gd-DTPA.
In vitro experiment reveals high uptake and retention abilities of the nanoprobes, while cell viability assay demonstrates excellent cytocompatibility of the dual-modality imaging probe.
After intratumor injection with the NIR/MR-MSNs, MR imaging shows clear anatomical border of the enhanced tumor region while NIR fluorescence exhibits high sensitive tumor detection ability.
These intriguing features suggest that this newly developed dual-modality imaging probes have great potential in biomedical imaging.
American Psychological Association (APA)
Fei-Peng, Zhu& Guo-Tao, Chen& Wang, Shouju& Ying, Liu& Yu-Xia, Tang& Tian, Ying…[et al.]. 2016. Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109314
Modern Language Association (MLA)
Fei-Peng, Zhu…[et al.]. Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109314
American Medical Association (AMA)
Fei-Peng, Zhu& Guo-Tao, Chen& Wang, Shouju& Ying, Liu& Yu-Xia, Tang& Tian, Ying…[et al.]. Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109314