Particle Size-Dependent Antibacterial Activity and Murine Cell Cytotoxicity Induced by Graphene Oxide Nanomaterials
Joint Authors
Zhao, Lin
Duan, Guangxin
Yang, Zaixing
Weber, Jeffrey K.
Liu, Xu
Lu, Shunyi
Meng, Xuanyu
Xu, JiaYing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recent studies have indicated that graphene and its derivative graphene oxide (GO) engage in a wide range of antibacterial activities with limited toxicity to human cells.
Here, we systematically evaluate the dependence of GO toxicity on the size of the nanoparticles used in treatments: we compare the cytotoxic effects of graphene quantum dots (GQDs, <15 nm), small GOs (SGOs, 50–200 nm), and large GOs (LGOs, 0.5–3 μm).
We synthesize the results of bacterial colony count assays and SEM-based observations of morphological changes to assess the antibacterial properties that these GOs bring into effect against E.
coli.
We also use Live/Dead assays and morphological analysis to investigate changes to mammalian (Murine macrophage-like Raw 264.7) cells induced by the presence of the various GO particle types.
Our results demonstrate that LGOs, SGOs, and GQDs possess antibacterial activities and cause mammalian cell cytotoxicity at descending levels of potency.
Placing our observations in the context of previous simulation results, we suggest that both the lateral size and surface area of GO particles contribute to cytotoxic effects.
We hope that the size dependence elucidated here provides a useful schematic for tuning GO-cell interactions in biomedical applications.
American Psychological Association (APA)
Zhao, Lin& Duan, Guangxin& Yang, Zaixing& Weber, Jeffrey K.& Liu, Xu& Lu, Shunyi…[et al.]. 2016. Particle Size-Dependent Antibacterial Activity and Murine Cell Cytotoxicity Induced by Graphene Oxide Nanomaterials. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109320
Modern Language Association (MLA)
Zhao, Lin…[et al.]. Particle Size-Dependent Antibacterial Activity and Murine Cell Cytotoxicity Induced by Graphene Oxide Nanomaterials. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109320
American Medical Association (AMA)
Zhao, Lin& Duan, Guangxin& Yang, Zaixing& Weber, Jeffrey K.& Liu, Xu& Lu, Shunyi…[et al.]. Particle Size-Dependent Antibacterial Activity and Murine Cell Cytotoxicity Induced by Graphene Oxide Nanomaterials. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109320