Poly-γ-Glutamic Acid Nanoparticles Based Visible Light-Curable Hydrogel for Biomedical Application
Joint Authors
Bakó, József
Kerényi, Farkas
Hrubi, Edit
Varga, István
Daróczi, Lajos
Dienes, Beatrix
Csernoch, László
Gáll, József
Hegedűs, Csaba
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nanoparticles and hydrogels have gained notable attention as promising potential for fabrication of scaffolds and delivering materials.
Visible light-curable systems can allow for the possibility of in situ fabrication and have the advantage of optimal applicability.
In this study nanogel was created from methacrylated poly-gamma-glutamic acid nanoparticles by visible (dental blue) light photopolymerization.
The average size of the particles was 80 nm by DLS, and the NMR spectra showed that the methacrylation rate was 10%.
Polymerization time was 3 minutes, and a stable nanogel with a swelling rate of 110% was formed.
The mechanical parameters of the prepared structure (compression stress 0.73 MPa, and Young’s modulus 0.93 MPa) can be as strong as necessary in a real situation, for example, in the mouth.
A retaining effect of the nanogel was found for ampicillin, and the biocompatibility of this system was tested by Alamar Blue proliferation assay, while the cell morphology was examined by fluorescence and laser scanning confocal microscopy.
In conclusion, the nanogel can be used for drug delivery, or it can be suitable for a control factor in different systems.
American Psychological Association (APA)
Bakó, József& Kerényi, Farkas& Hrubi, Edit& Varga, István& Daróczi, Lajos& Dienes, Beatrix…[et al.]. 2016. Poly-γ-Glutamic Acid Nanoparticles Based Visible Light-Curable Hydrogel for Biomedical Application. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109355
Modern Language Association (MLA)
Bakó, József…[et al.]. Poly-γ-Glutamic Acid Nanoparticles Based Visible Light-Curable Hydrogel for Biomedical Application. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109355
American Medical Association (AMA)
Bakó, József& Kerényi, Farkas& Hrubi, Edit& Varga, István& Daróczi, Lajos& Dienes, Beatrix…[et al.]. Poly-γ-Glutamic Acid Nanoparticles Based Visible Light-Curable Hydrogel for Biomedical Application. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109355