Combination of Photodynamic Therapy with Radiotherapy for Cancer Treatment
Joint Authors
Gao, Jian-Qing
Xu, Jing
Wei, Qichun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Photodynamic therapy (PDT) is a promising treatment modality for the management of malignant diseases.
However, general acceptance of PDT has been hampered due to the limited tissue penetration of light and unavailability of suitable photosensitizers (PSs).
The innovative combination of the conventional radiotherapy (RT) with PDT might reduce the unacceptable normal tissue toxicity while maintaining the desired tumor suppression effect.
There have been a number of attempts to examine the interaction of PDT and RT; however, the previous results presented are ambiguous.
The exact mechanisms for the variable responses of diverse panel of cell lines to the combination therapeutic regimen are still unclear.
Novel ways are being explored to overcome the weaknesses of the conventional PDT and RT treatment regimen.
The novel application to enable PDT of deep cancers is the utilization of scintillating nanoparticles as an intracellular light source for PDT activation.
Upon simulation by X-rays, the nanoparticles emit scintillation or persistent luminescence to activate the PS to generate singlet oxygen.
For future clinical applications, several questions are worthy of further elucidation, including the specific light dose, PS dose, radiation dose, the risk of complications, and the accurate time interval between administration of PDT and administration of RT.
American Psychological Association (APA)
Xu, Jing& Gao, Jian-Qing& Wei, Qichun. 2016. Combination of Photodynamic Therapy with Radiotherapy for Cancer Treatment. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109433
Modern Language Association (MLA)
Xu, Jing…[et al.]. Combination of Photodynamic Therapy with Radiotherapy for Cancer Treatment. Journal of Nanomaterials No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1109433
American Medical Association (AMA)
Xu, Jing& Gao, Jian-Qing& Wei, Qichun. Combination of Photodynamic Therapy with Radiotherapy for Cancer Treatment. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109433