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PLGANano-ZnO Composite Particles for Use in Biomedical Applications: Preparation, Characterization, and Antimicrobial Activity
Joint Authors
Stanković, Ana
Sezen, Meltem
Milenković, Marina
Kaišarević, Sonja
Andrić, Nebojša
Stevanović, Magdalena
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Copolymer poly (DL-lactide-co-glycolide) (PLGA) is extensively investigated for various biomedical applications such as controlled drug delivery or carriers in the tissue engineering.
In addition, zinc oxide (ZnO) is widely used in biomedicine especially for materials like dental composites, as a constituent of creams for the treatment of a variety of skin irritations, to enhance the antibacterial activity of different medicaments and so on.
Uniform, spherical ZnO nanoparticles (nano-ZnO) have been synthesized via microwave synthesis method.
In addition to obtaining nano-ZnO, a further aim was to examine their immobilization in the PLGA polymer matrix (PLGA/nano-ZnO) and this was done by a simple physicochemical solvent/nonsolvent method.
The samples were characterized by X-ray diffraction, scanning electron microscopy, laser diffraction particle size analyzer, differential thermal analysis, and thermal gravimetric analysis.
The synthesized PLGA/nano-ZnO particles are spherical, uniform, and with diameters below 1 µm.
The influence of the different solvents and the drying methods during the synthesis was investigated too.
The biocompatibility of the samples is discussed in terms of in vitro toxicity on human hepatoma HepG2 cells by application of MTT assay and the antimicrobial activity was evaluated by broth microdilution method against different groups of microorganisms (Gram-positive bacteria, Gram-negative bacteria, and yeast Candida albicans).
American Psychological Association (APA)
Stanković, Ana& Sezen, Meltem& Milenković, Marina& Kaišarević, Sonja& Andrić, Nebojša& Stevanović, Magdalena. 2016. PLGANano-ZnO Composite Particles for Use in Biomedical Applications: Preparation, Characterization, and Antimicrobial Activity. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109506
Modern Language Association (MLA)
Stanković, Ana…[et al.]. PLGANano-ZnO Composite Particles for Use in Biomedical Applications: Preparation, Characterization, and Antimicrobial Activity. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109506
American Medical Association (AMA)
Stanković, Ana& Sezen, Meltem& Milenković, Marina& Kaišarević, Sonja& Andrić, Nebojša& Stevanović, Magdalena. PLGANano-ZnO Composite Particles for Use in Biomedical Applications: Preparation, Characterization, and Antimicrobial Activity. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109506