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Antibacterial Activity of Partially Oxidized AgAu Nanoparticles against the Oral Pathogen Porphyromonas gingivalis W83
Joint Authors
Wilson, Aruni
Holden, Megan S.
Black, Jason
Lewis, Ainsely
Boutrin, Marie-Claire
Walemba, Elvin
Sabir, Theodore S.
Boskovic, Danilo S.
Fletcher, Hansel M.
Perry, Christopher C.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Advances in nanotechnology provide opportunities for the prevention and treatment of periodontal disease.
While physicochemical properties of Ag containing nanoparticles (NPs) are known to influence the magnitude of their toxicity, it is thought that nanosilver can be made less toxic to eukaryotes by passivation of the NPs with a benign metal.
Moreover, the addition of other noble metals to silver nanoparticles, in the alloy formulation, is known to alter the silver dissolution behavior.
Thus, we synthesized glutathione capped Ag/Au alloy bimetallic nanoparticles (NPs) via the galvanic replacement reaction between maltose coated Ag NPs and chloroauric acid (HAuCl4) in 5% aqueous triblock F127 copolymer solution.
We then compared the antibacterial activity of the Ag/Au NPs to pure Ag NPs on Porphyromonas gingivalis W83, a key pathogen in the development of periodontal disease.
Only partially oxidized glutathione capped Ag and Ag/Au (Au : Ag ≈ 0.2) NPs inhibited the planktonic growth of P.
gingivalis W83.
This effect was enhanced in the presence of hydrogen peroxide, which simulates the oxidative stress environment in the periodontal pocket during chronic inflammation.
American Psychological Association (APA)
Holden, Megan S.& Black, Jason& Lewis, Ainsely& Boutrin, Marie-Claire& Walemba, Elvin& Sabir, Theodore S.…[et al.]. 2016. Antibacterial Activity of Partially Oxidized AgAu Nanoparticles against the Oral Pathogen Porphyromonas gingivalis W83. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109523
Modern Language Association (MLA)
Holden, Megan S.…[et al.]. Antibacterial Activity of Partially Oxidized AgAu Nanoparticles against the Oral Pathogen Porphyromonas gingivalis W83. Journal of Nanomaterials No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1109523
American Medical Association (AMA)
Holden, Megan S.& Black, Jason& Lewis, Ainsely& Boutrin, Marie-Claire& Walemba, Elvin& Sabir, Theodore S.…[et al.]. Antibacterial Activity of Partially Oxidized AgAu Nanoparticles against the Oral Pathogen Porphyromonas gingivalis W83. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109523