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Improved Delivery of Caffeic Acid through Liposomal Encapsulation
Joint Authors
Karunaratne, Veranja
Karunaratne, D. Nedra
Katuwavila, Nuwanthi P.
Perera, A. D. L. Chandani
Amaratunga, Gehan A. J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Photoageing resulting from long term exposure of the skin to UV light can be minimized by scavenging the reactive photochemical intermediates with antioxidants.
For effective photoprotection, the antioxidant must overcome the barrier properties of the skin and reach the target site in significant amounts.
The present study aims to improve the skin penetration of caffeic acid, a very effective free radical scavenger, by encapsulating in liposomes.
Caffeic acid loaded liposomes prepared using the reverse phase evaporation technique showed 70% encapsulation efficiency and size around 100 nm with zeta potential of −55 mV.
In vitro diffusion through a dialysis membrane enabled 70% release of encapsulated caffeic acid within 7 h, whereas 95% of free caffeic acid diffused within 4 h in PBS solution (pH 7.4).
Liposomal caffeic acid permeation through pig skin epidermis in a Franz cell apparatus was 45 % during 7 h.
In contrast, free caffeic acid was almost nonpermeable (<5%) to pig skin during this time.
The DPPH assay indicated that skin penetration did not destroy the antioxidant activity of liposomal caffeic acid or free caffeic acid.
In conclusion, we confirm that liposomal caffeic acid may be successfully employed as an effective photoprotective agent against UV mediated skin damage.
American Psychological Association (APA)
Katuwavila, Nuwanthi P.& Perera, A. D. L. Chandani& Karunaratne, Veranja& Amaratunga, Gehan A. J.& Karunaratne, D. Nedra. 2016. Improved Delivery of Caffeic Acid through Liposomal Encapsulation. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109533
Modern Language Association (MLA)
Katuwavila, Nuwanthi P.…[et al.]. Improved Delivery of Caffeic Acid through Liposomal Encapsulation. Journal of Nanomaterials No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1109533
American Medical Association (AMA)
Katuwavila, Nuwanthi P.& Perera, A. D. L. Chandani& Karunaratne, Veranja& Amaratunga, Gehan A. J.& Karunaratne, D. Nedra. Improved Delivery of Caffeic Acid through Liposomal Encapsulation. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109533