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New Bismuth Germanate Oxide Nanoparticle Material for Biolabel Applications in Medicine
Joint Authors
Soares Macedo, Zélia
Oviedo, Mariana J.
Carbajal Arizaga, Gregorio Guadalupe
Rosenstein, Y.
Vazquez-Duhalt, R.
Hirata, G. A.
Contreras-López, O. E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bismuth germanate (Bi4Ge3O12, BGO) has been the focus of several studies due to its scintillation properties.
It has been employed as detector in scientific research and medicine, and herein we studied its possible biomedical applications.
The photoluminescence properties of the uncoated and protein-coated nanoparticles were analyzed in different body fluids, at different pH.
The nanoparticles yielded blueish-white luminescence with a maximum emission peak at 485 nm corresponding to the 3P1 → 1S0 electron transition of Bi3+.
They showed luminescence properties at different pH values and in human fluids, such as urine and blood serum.
Finally, the BGO nanoparticles were functionalized with the anti-HLA I W6/32 monoclonal antibody and the capacity of the antibody-loaded nanoparticles to recognize the cognate antigen (HLA I) of the W6/32 mAb was assessed on the human promyelocytic leukemia cell line THP-1.
The possibility of functionalizing BGO nanoparticles with W6/32 antibodies and their specificity to identify THP-1 cells make them promising candidates for biomedical applications as biolabels.
American Psychological Association (APA)
Oviedo, Mariana J.& Contreras-López, O. E.& Rosenstein, Y.& Vazquez-Duhalt, R.& Soares Macedo, Zélia& Carbajal Arizaga, Gregorio Guadalupe…[et al.]. 2016. New Bismuth Germanate Oxide Nanoparticle Material for Biolabel Applications in Medicine. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109539
Modern Language Association (MLA)
Oviedo, Mariana J.…[et al.]. New Bismuth Germanate Oxide Nanoparticle Material for Biolabel Applications in Medicine. Journal of Nanomaterials No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109539
American Medical Association (AMA)
Oviedo, Mariana J.& Contreras-López, O. E.& Rosenstein, Y.& Vazquez-Duhalt, R.& Soares Macedo, Zélia& Carbajal Arizaga, Gregorio Guadalupe…[et al.]. New Bismuth Germanate Oxide Nanoparticle Material for Biolabel Applications in Medicine. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109539