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A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
According to previous reports, low pH-triggered nanoparticles were considered to be excellent carriers for anticancer drug delivery, for the reason that they could trigger encapsulated drug release at mild acid environment of tumor.
Herein, an acid-sensitive β-cyclodextrin derivative, namely, acetalated-β-cyclodextrin (Ac-β-CD), was synthesized by acetonation and fabricated to nanoparticles through single oil-in-water (o/w) emulsion technique.
At the same time, camptothecin (CPT), a hydrophobic anticancer drug, was encapsulated into Ac-β-CD nanoparticles in the process of nanoparticle fabrication.
Formed nanoparticles exhibited nearly spherical structure with diameter of 209 ± 40 nm.
The drug release behavior of nanoparticles displayed pH dependent changes due to hydrolysis of Ac-β-CD.
In order to overcome the disadvantages of nanoparticle and broaden its application, injectable hydrogels with Ac-β-CD nanoparticles were designed and prepared by simple mixture of nanoparticles solution and graphene oxide (GO) solution in this work.
The injectable property was confirmed by short gelation time and good mobility of two precursors.
Hydrogels were characterized by dynamic mechanical test and SEM, which also reflected some structural features.
Moreover, all hydrogels underwent a reversible sol-gel transition in alkaline environment.
Finally, the results of in vitro drug release profile indicated that hydrogel could control drug release or bind drug inside depending on the pH value of released medium.
American Psychological Association (APA)
Ye, Yuanfeng& Zhang, Guojun. 2016. A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109547
Modern Language Association (MLA)
Ye, Yuanfeng& Zhang, Guojun. A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery. Journal of Nanomaterials No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109547
American Medical Association (AMA)
Ye, Yuanfeng& Zhang, Guojun. A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109547