Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study
Joint Authors
Stoner, Lee
Oliver, Jonathan M.
Rowlands, David S.
Caldwell, Aaron R.
Sanders, Elizabeth
Kreutzer, Andreas
Mitchell, Joel B.
Purpura, Martin
Jäger, Ralf
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Curcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function.
In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50 mg (50 mg), or 200 mg (200 mg) curcumin, for 8 weeks.
The higher curcumin (200 mg) supplementation produced a dose-mediated improvement in endothelial function measured by flow-mediated dilation (FMD).
The outcome was a clinically substantial 3.0% increase (90% CI 0.7 to 5.3%, p = 0.032 ; benefit : harm odds ratio 546 : 1) with the 200 mg dose, relative to placebo.
The 50 mg dose also increased FMD relative to placebo by 1.7% (−0.6 to 4.0%, p = 0.23 ; 25 : 1), but the outcome was not clinically decisive.
In apparently healthy adults, 8 weeks of 200 mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD.
Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases.
This trial was registered at ISRCTN registry (ISRCTN90184217).
American Psychological Association (APA)
Oliver, Jonathan M.& Stoner, Lee& Rowlands, David S.& Caldwell, Aaron R.& Sanders, Elizabeth& Kreutzer, Andreas…[et al.]. 2016. Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109568
Modern Language Association (MLA)
Oliver, Jonathan M.…[et al.]. Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109568
American Medical Association (AMA)
Oliver, Jonathan M.& Stoner, Lee& Rowlands, David S.& Caldwell, Aaron R.& Sanders, Elizabeth& Kreutzer, Andreas…[et al.]. Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109568