Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis
Joint Authors
van Leeuwen, P. A. M.
Vermeulen, Mechteld A. R.
Brinkmann, Saskia J. H.
Buijs, Nikki
Beishuizen, Albertus
Bet, Pierre M.
van Goudoever, Johannes B.
Houdijk, Alexander P. J.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Glutamine supplementation in specific groups of critically ill patients results in favourable clinical outcome.
Enhancement of citrulline and arginine synthesis by glutamine could serve as a potential mechanism.
However, while receiving optimal enteral nutrition, uptake and enteral metabolism of glutamine in critically ill patients remain unknown.
Therefore we investigated the effect of a therapeutically relevant dose of L-glutamine on synthesis of L-citrulline and subsequent L-arginine in this group.
Ten versus ten critically ill patients receiving full enteral nutrition, or isocaloric isonitrogenous enteral nutrition including 0.5 g/kg L-alanyl-L-glutamine, were studied using stable isotopes.
A cross-over design using intravenous and enteral tracers enabled splanchnic extraction (SE) calculations.
Endogenous rate of appearance and SE of glutamine citrulline and arginine was not different (SE controls versus alanyl-glutamine: glutamine 48 and 48%, citrulline 33 versus 45%, and arginine 45 versus 42%).
Turnover from glutamine to citrulline and arginine was not higher in glutamine-administered patients.
In critically ill nonseptic patients receiving adequate nutrition and a relevant dose of glutamine there was no extra citrulline or arginine synthesis and glutamine SE was not increased.
This suggests that for arginine synthesis enhancement there is no need for an additional dose of glutamine when this population is adequately fed.
This trial is registered with NTR2285.
American Psychological Association (APA)
Vermeulen, Mechteld A. R.& Brinkmann, Saskia J. H.& Buijs, Nikki& Beishuizen, Albertus& Bet, Pierre M.& Houdijk, Alexander P. J.…[et al.]. 2016. Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1109570
Modern Language Association (MLA)
Vermeulen, Mechteld A. R.…[et al.]. Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1109570
American Medical Association (AMA)
Vermeulen, Mechteld A. R.& Brinkmann, Saskia J. H.& Buijs, Nikki& Beishuizen, Albertus& Bet, Pierre M.& Houdijk, Alexander P. J.…[et al.]. Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1109570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109570