Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia
Joint Authors
Khan, Naim Akhtar
Hichami, Aziz
Grissa, O.
Mrizak, I.
Benammar, C.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Th (T helper) cells are differentiated into either Th1 or Th2 phenotype.
It is generally considered that Th1 phenotype is proinflammatory, whereas Th2 phenotype exerts anti-inflammatory or protective effects.
Gestational diabetes mellitus (GDM) has been associated with a decreased Th1 phenotype, whereas macrosomia is marked with high expression of Th1 cytokines.
Besides, these two pathological situations are marked with high concentrations of inflammatory mediators like tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), known to play a pivotal role in insulin resistance.
Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert a beneficial effect by shifting Th1/Th2 balance to a Th2 phenotype and increasing insulin sensitivity.
In this paper, we shed light on the role of T-cell malfunction that leads to an inflammatory and pathophysiological state, related to insulin resistance in GDM and macrosomia.
We will also discuss the nutritional management of these pathologies by dietary n-3 polyunsaturated fatty acids (PUFAs).
American Psychological Association (APA)
Hichami, Aziz& Grissa, O.& Mrizak, I.& Benammar, C.& Khan, Naim Akhtar. 2016. Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109583
Modern Language Association (MLA)
Hichami, Aziz…[et al.]. Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109583
American Medical Association (AMA)
Hichami, Aziz& Grissa, O.& Mrizak, I.& Benammar, C.& Khan, Naim Akhtar. Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109583