Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions
Joint Authors
Danner, Omar K.
Matthews, Leslie R.
Francis, Sharon
Rao, Veena N.
Harvey, Cassie P.
Tobin, Richard P.
Wilson, Ken L.
Alema-Mensah, Ernest
Newell Rogers, M. Karen
Childs, Ed W.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Class II invariant chain peptide (CLIP) expression has been demonstrated to play a pivotal role in the regulation of B cell function after nonspecific polyclonal expansion.
Several studies have shown vitamin D3 helps regulate the immune response.
We hypothesized that activated vitamin D3 suppresses CLIP expression on activated B-cells after nonspecific activation or priming of C57BL/6 mice with CpG.
This study showed activated vitamin D3 actively reduced CLIP expression and decreased the number of CLIP+ B-lymphocytes in a dose and formulation dependent fashion.
Flow cytometry was used to analyze changes in mean fluorescent intensity (MFI) based on changes in concentration of CLIP on activated B-lymphocytes after treatment with the various formulations of vitamin D3.
The human formulation of activated vitamin D (calcitriol) had the most dramatic reduction in CLIP density at an MFI of 257.3 [baseline of 701.1 ( P value = 0.01)].
Cholecalciferol and alfacalcidiol had no significant reduction in MFI at 667.7 and 743.0, respectively.
Calcitriol seemed to best reduce CLIP overexpression in this ex vivo model.
Bioactive vitamin D3 may be an effective compliment to other B cell suppression therapeutics to augment downregulation of nonspecific inflammation associated with many autoimmune disorders.
Further study is necessary to confirm these findings.
American Psychological Association (APA)
Danner, Omar K.& Matthews, Leslie R.& Francis, Sharon& Rao, Veena N.& Harvey, Cassie P.& Tobin, Richard P.…[et al.]. 2016. Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109589
Modern Language Association (MLA)
Danner, Omar K.…[et al.]. Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109589
American Medical Association (AMA)
Danner, Omar K.& Matthews, Leslie R.& Francis, Sharon& Rao, Veena N.& Harvey, Cassie P.& Tobin, Richard P.…[et al.]. Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109589