Increased Gustatory Response Score in Obesity and Association Levels with IL-6 and Leptin
Joint Authors
Remla, Nesrine
Hadjidj, Zeyneb
Ghezzaz, Kamel
Moulessehoul, Soraya
Aribi, Mourad
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The aim of this study was to investigate the relationship between the circulating IL-6 and leptin levels with taste alteration in young obese patients.
Methods.
A retrospective case-control study was conducted in thirty obese patients and thirty age- and sex-matched healthy controls.
Results.
Circulating levels of IL-6 and leptin were significantly increased in obese patients than in controls.
However, catalase and ORAC levels were significantly decreased in obese patients compared to controls.
Additionally, obese participants had high scores for the detection of fats (gustatory response scores [GRS]; p < 0.001 ).
Moreover, IL-6 and leptin were strongly associated with GRS alteration among patients with GRS 4 (resp., OR =17.5 [95% CI, 1.56–193.32; p = 0.007 ]; OR = 16 [95% CI, 1.69–151.11; p = 0.006 ]).
For the Mantel-Haenszel common odds ratio estimate (MH OR), IL-6 and leptin were strongly associated with obesity, in patients with either GRS 4 or GRS > 4 (resp., MH OR = 8.77 [95% CI, 2.06–37.44; p = 0.003 ]; MH OR = 5.76 [95% CI, 1.64–20.24; p = 0.006 ]).
Conclusions.
In a low grade inflammation linked to obesity, taste alteration is associated with high levels of IL-6 and leptin.
American Psychological Association (APA)
Remla, Nesrine& Hadjidj, Zeyneb& Ghezzaz, Kamel& Moulessehoul, Soraya& Aribi, Mourad. 2016. Increased Gustatory Response Score in Obesity and Association Levels with IL-6 and Leptin. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109613
Modern Language Association (MLA)
Remla, Nesrine…[et al.]. Increased Gustatory Response Score in Obesity and Association Levels with IL-6 and Leptin. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109613
American Medical Association (AMA)
Remla, Nesrine& Hadjidj, Zeyneb& Ghezzaz, Kamel& Moulessehoul, Soraya& Aribi, Mourad. Increased Gustatory Response Score in Obesity and Association Levels with IL-6 and Leptin. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109613