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Release of siRNA from Liposomes Induced by Curcumin
Joint Authors
Fujita, Kazuyo
Hiramatsu, Yoshie
Minematsu, Hideki
Somiya, Masaharu
Kuroda, Shun’ichi
Hinuma, Shuji
Seno, Masaharu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS).
In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min.
However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin.
Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin.
About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions.
Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA.
American Psychological Association (APA)
Fujita, Kazuyo& Hiramatsu, Yoshie& Minematsu, Hideki& Somiya, Masaharu& Kuroda, Shun’ichi& Seno, Masaharu…[et al.]. 2016. Release of siRNA from Liposomes Induced by Curcumin. Journal of Nanotechnology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109679
Modern Language Association (MLA)
Fujita, Kazuyo…[et al.]. Release of siRNA from Liposomes Induced by Curcumin. Journal of Nanotechnology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109679
American Medical Association (AMA)
Fujita, Kazuyo& Hiramatsu, Yoshie& Minematsu, Hideki& Somiya, Masaharu& Kuroda, Shun’ichi& Seno, Masaharu…[et al.]. Release of siRNA from Liposomes Induced by Curcumin. Journal of Nanotechnology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109679