Does the Degree of Hepatocellular Carcinoma Tumor Necrosis following Transarterial Chemoembolization Impact Patient Survival?
Joint Authors
Saddekni, Souheil
DuBay, Derek
Haywood, Nathan
Gennaro, Kyle
Obert, John
Sauer, Paul F.
Redden, David T.
Zarzour, Jessica
Smith, J. Kevin
Bolus, David
Gray, Stephen
White, Jared
Eckhoff, Devin
Abdel-Aal, Ahmed Kamel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
The association between transarterial chemoembolization- (TACE-) induced HCC tumor necrosis measured by the modified Response Evaluation Criteria In Solid Tumors (mRECIST) and patient survival is poorly defined.
We hypothesize that survival will be superior in HCC patients with increased TACE-induced tumor necrosis.
Materials and Methods.
TACE interventions were retrospectively reviewed.
Tumor response was quantified via dichotomized (responders and nonresponders) and the four defined mRECIST categories.
Results.
Median survival following TACE was significantly greater in responders compared to nonresponders (20.8 months versus 14.9 months, p=0.011).
Survival outcomes also significantly varied among the four mRECIST categories (p=0.0003): complete, 21.4 months; partial, 20.8; stable, 16.8; and progressive, 7.73.
Only progressive disease demonstrated significantly worse survival when compared to complete response.
Multivariable analysis showed that progressive disease, increasing total tumor diameter, and non-Child-Pugh class A were independent predictors of post-TACE mortality.
Conclusions.
Both dichotomized (responders and nonresponders) and the four defined mRECIST responses to TACE in patients with HCC were predictive of survival.
The main driver of the survival analysis was poor survival in the progressive disease group.
Surprisingly, there was small nonsignificant survival benefit between complete, partial, and stable disease groups.
These findings may inform HCC treatment decisions following first TACE.
American Psychological Association (APA)
Haywood, Nathan& Gennaro, Kyle& Obert, John& Sauer, Paul F.& Redden, David T.& Zarzour, Jessica…[et al.]. 2016. Does the Degree of Hepatocellular Carcinoma Tumor Necrosis following Transarterial Chemoembolization Impact Patient Survival?. Journal of Oncology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109699
Modern Language Association (MLA)
Haywood, Nathan…[et al.]. Does the Degree of Hepatocellular Carcinoma Tumor Necrosis following Transarterial Chemoembolization Impact Patient Survival?. Journal of Oncology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109699
American Medical Association (AMA)
Haywood, Nathan& Gennaro, Kyle& Obert, John& Sauer, Paul F.& Redden, David T.& Zarzour, Jessica…[et al.]. Does the Degree of Hepatocellular Carcinoma Tumor Necrosis following Transarterial Chemoembolization Impact Patient Survival?. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109699