Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation
Joint Authors
Hirata, Keiji
Kohi, Shiro
Sato, Norihiro
Koga, Atsuhiro
Harunari, Enjuro
Igarashi, Yasuhiro
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Pancreatic ductal adenocarcinoma (PDAC) is characterized by accelerated production and degradation of hyaluronan (HA), a major component of extracellular matrix involved in the malignant phenotype of cancer.
In particular, increased hyaluronidase (HYAL) activity plays a critical role in cancer progression, at least in part, by producing low-molecular-weight- (LMW-) HA or small fragments of HA, suggesting HYAL as a target for cancer treatment.
Hyaluromycin, a new member of the rubromycin family of antibiotics, was isolated from the culture extract of a marine-derived Streptomyces hyaluromycini as a HYAL inhibitor.
We investigated the antitumor effects of hyaluromycin in PDAC cells.
We examined the effects of hyaluromycin on the proliferation and migration of PDAC cells.
To elucidate the mechanisms underlying the effect of hyaluromycin on PDAC cells, we examined the concentration of LMW-HA in the conditioned media after treating PDAC cells with hyaluromycin.
We demonstrate that hyaluromycin inhibits proliferation and migration of PDAC cells.
We also found that these antitumor effects of hyaluromycin were associated with a decreased concentration of LMW-HA and a decreased phosphorylation of ribosomal protein S6.
Our results suggest that hyaluromycin is a promising new drug against this highly aggressive neoplasm.
American Psychological Association (APA)
Kohi, Shiro& Sato, Norihiro& Koga, Atsuhiro& Hirata, Keiji& Harunari, Enjuro& Igarashi, Yasuhiro. 2016. Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation. Journal of Oncology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109715
Modern Language Association (MLA)
Kohi, Shiro…[et al.]. Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation. Journal of Oncology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109715
American Medical Association (AMA)
Kohi, Shiro& Sato, Norihiro& Koga, Atsuhiro& Hirata, Keiji& Harunari, Enjuro& Igarashi, Yasuhiro. Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109715
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109715