The Oncogenic Functions of Nicotinic Acetylcholine Receptors
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nicotinic acetylcholine receptors (nAChRs) are ion channels that are expressed in the cell membrane of all mammalian cells, including cancer cells.
Recent findings suggest that nAChRs not only mediate nicotine addiction in the brain but also contribute to the development and progression of cancers directly induced by nicotine and its derived carcinogenic nitrosamines whereas deregulation of the nAChRs is observed in many cancers, and genome-wide association studies (GWAS) indicate that SNPs nAChRs associate with risks of lung cancers and nicotine addiction.
Emerging evidences suggest nAChRs are posited at the central regulatory loops of numerous cell growth and prosurvival signal pathways and also mediate the synthesis and release of stimulatory and inhibitory neurotransmitters induced by their agonists.
Thus nAChRs mediated cell signaling plays an important role in stimulating the growth and angiogenic and neurogenic factors and mediating oncogenic signal transduction during cancer development in a cell type specific manner.
In this review, we provide an integrated view of nAChRs signaling in cancer, heightening on the oncogenic properties of nAChRs that may be targeted for cancer treatment.
American Psychological Association (APA)
Zhao, Yue. 2016. The Oncogenic Functions of Nicotinic Acetylcholine Receptors. Journal of Oncology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109716
Modern Language Association (MLA)
Zhao, Yue. The Oncogenic Functions of Nicotinic Acetylcholine Receptors. Journal of Oncology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109716
American Medical Association (AMA)
Zhao, Yue. The Oncogenic Functions of Nicotinic Acetylcholine Receptors. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109716