Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People
Joint Authors
Khan, Abidullah
Humayun, Mohammad
Ayub, Maimoona
Khan, Wazir Mohammad
Haroon, Mohammad
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
In clinical practice, serum ferritin is used as a screening tool to detect iron deficiency.
However, its reliability in obesity has been questioned.
Objectives.
To investigate the role of ferritin in overweight and obese people, either as a marker of inflammation or iron deficiency.
Methods.
On the basis of body mass index (BMI), 150 participants were divided into three equal groups: A: BMI 18.5–25 kg/m2, B: BMI 25–30 kg/m2, and C: B M I > 30 kg/m2.
Serum iron, total iron binding capacity (TIBC), transferrin saturation, ferritin, C-reactive protein, and hemoglobin (Hb) were measured for each participant and analyzed through SPSS version 16.
One-way ANOVA and Pearson’s correlation tests were applied.
Results.
Ferritin was the highest in group C ( M = 163.48 ± 2.23 , P < 0.001 ) and the lowest in group A, ( M = 152.78 ± 1.81 , P < 0.001 ).
Contrarily to ferritin, transferrin was the lowest in group C, ( M = 30.65 ± 1.39 , P < 0.001 ) and the highest in group A, ( M = 38.66 ± 2.14 , P < 0.001 ).
Ferritin had a strong positive correlation with both BMI ( r = 0.86 , P < 0.001 ) and CRP ( r = 0.87 , P < 0.001 ) and strong negative correlation with Hb, iron, TIBC, and transferrin saturation ( P < 0.001 ).
Conclusion.
Ferritin is a marker of inflammation rather than iron status in overweight and obese people.
Complete iron profile including transferrin, rather than serum ferritin alone, can truly predict iron deficiency in such people.
American Psychological Association (APA)
Khan, Abidullah& Khan, Wazir Mohammad& Ayub, Maimoona& Humayun, Mohammad& Haroon, Mohammad. 2016. Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People. Journal of Obesity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109721
Modern Language Association (MLA)
Khan, Abidullah…[et al.]. Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People. Journal of Obesity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1109721
American Medical Association (AMA)
Khan, Abidullah& Khan, Wazir Mohammad& Ayub, Maimoona& Humayun, Mohammad& Haroon, Mohammad. Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People. Journal of Obesity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109721