Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery
Joint Authors
Argyropoulos, George A.
Still, Christopher D.
Gerhard, Glenn S.
Noel, Olivier F.
Edwards, Michael
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Overweight and obesity represent major risk factors for diabetes and related metabolic diseases.
Obesity is associated with a chronic and progressive inflammatory response leading to the development of insulin resistance and type 2 diabetes (T2D) mellitus, although the precise mechanism mediating this inflammatory process remains poorly understood.
The most effective intervention for the treatment of obesity, bariatric surgery, leads to glucose normalization and remission of T2D.
Recent work in both clinical studies and animal models supports bile acids (BAs) as key mediators of these effects.
BAs are involved in lipid and glucose homeostasis primarily via the farnesoid X receptor (FXR) transcription factor.
BAs are also involved in regulating genes involved in inflammation, obesity, and lipid metabolism.
Here, we review the novel role of BAs in bariatric surgery and the intersection between BAs and immune, obesity, weight loss, and lipid metabolism genes.
American Psychological Association (APA)
Noel, Olivier F.& Still, Christopher D.& Argyropoulos, George A.& Edwards, Michael& Gerhard, Glenn S.. 2016. Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery. Journal of Obesity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109746
Modern Language Association (MLA)
Noel, Olivier F.…[et al.]. Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery. Journal of Obesity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109746
American Medical Association (AMA)
Noel, Olivier F.& Still, Christopher D.& Argyropoulos, George A.& Edwards, Michael& Gerhard, Glenn S.. Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery. Journal of Obesity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109746