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Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis
Joint Authors
Li, Xuan
Xiang, Yang
Dong, Yi
Tang, Xin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG).
Methods.
After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the polymorphisms (rs2070744 and rs1799983) of eNOS gene and POAG were screened and included.
The pooled odds ratios (ORs) and the 95% confidence interval (CI) of each single-nucleotide polymorphism (SNP) in five genetic models were estimated using fixed-effect model if I 2 < 50 % in the test for heterogeneity; otherwise the random-effects model was used.
Results.
Thirty-one records were obtained, with five being suitable for meta-analysis.
The overall results showed that both TT genotype in rs2070744 and GG genotype in rs1799983 are associated with decreased risk of POAG susceptibility.
Stratified analysis based on ethnicity showed that the association of rs2070744 with POAG remained only in Caucasians.
Results of subgroup analysis by sex indicated association between both polymorphisms and POAG in female group, but not in male group.
Conclusions.
TT genotype and/or T-allele in rs2070744, as well as GG genotype and/or G-allele in rs1799983, was associated with decreased risk for POAG overall and in female group.
American Psychological Association (APA)
Xiang, Yang& Dong, Yi& Li, Xuan& Tang, Xin. 2016. Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109829
Modern Language Association (MLA)
Xiang, Yang…[et al.]. Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis. Journal of Ophthalmology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1109829
American Medical Association (AMA)
Xiang, Yang& Dong, Yi& Li, Xuan& Tang, Xin. Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109829