Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis
Joint Authors
Kolbe, Scott C.
Walt, Anneke van der
Klistorner, Alexander
Egan, Gary F.
Kilpatrick, Trevor J.
Butzkueven, Helmut
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Previous studies have reported diffusion tensor imaging (DTI) changes within the optic radiations of patients after optic neuritis (ON).
We aimed to study optic radiation DTI changes over 12 months following acute ON and to study correlations between DTI parameters and damage to the optic nerve and primary visual cortex (V1).
We measured DTI parameters [fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] from the optic radiations of 38 acute ON patients at presentation and 6 and 12 months after acute ON.
In addition, we measured retinal nerve fibre layer thickness, visual evoked potential amplitude, optic radiation lesion load, and V1 thickness.
At baseline, FA was reduced and RD and MD were increased compared to control.
Over 12 months, FA reduced in patients at an average rate of −2.6% per annum (control = −0.51%; p = 0.006 ).
Change in FA, RD, and MD correlated with V1 thinning over 12 months (FA: R = 0.450 , p = 0.006 ; RD: R = - 0.428 , p = 0.009 ; MD: R = - 0.365 , p = 0.029 ).
In patients with no optic radiation lesions, AD significantly correlated with RNFL thinning at 12 months ( R = 0.489 , p = 0.039 ).
In conclusion, DTI can detect optic radiation changes over 12 months following acute ON that correlate with optic nerve and V1 damage.
American Psychological Association (APA)
Kolbe, Scott C.& Walt, Anneke van der& Butzkueven, Helmut& Klistorner, Alexander& Egan, Gary F.& Kilpatrick, Trevor J.. 2016. Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109904
Modern Language Association (MLA)
Kolbe, Scott C.…[et al.]. Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis. Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109904
American Medical Association (AMA)
Kolbe, Scott C.& Walt, Anneke van der& Butzkueven, Helmut& Klistorner, Alexander& Egan, Gary F.& Kilpatrick, Trevor J.. Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109904