A Meta-Analysis of Studies Evaluating Visual and Anatomical Outcomes in Patients with Treatment Resistant Neovascular Age-Related Macular Degeneration following Switching to Treatment with Aflibercept
Joint Authors
Tomkins, Oren
Lightman, Susan L.
Seguin-Greenstein, Sophie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
With the introduction of aflibercept, eyes with neovascular age-related macular degeneration (AMD) not responding well to injections of ranibizumab or bevacizumab can be switched to treatment with aflibercept.
We carried out a meta-analysis to analyze all available evidence of visual and anatomical outcomes of eyes with resistant neovascular AMD switched to aflibercept at six months.
Data from seven retrospective and prospective studies looking at change in best corrected visual acuity (BCVA) and central retinal thickness (CRT) were included.
Weighted mean difference (WMD) and 95% CI were estimated using the standardized mean change method.
The overall results of the meta-analysis showed a small but statistically significant improvement in BCVA six months following treatment switch to aflibercept (WMD 0.142, 95% CI 0.006 to 0.28; p = 0.04 ), and the effect was more significant in data gathered from prospective studies (WMD 0.407, 95% CI 0.023 to 0.791, p = 0.038 ).
There was a significant improvement in CRT following treatment switch to aflibercept (WMD −0.36, 95% CI −0.485 to −0.235; p < 0.0001 ).
Our meta-analysis indicates that following treatment switch to aflibercept patients may have a significant improvement in CRT with stabilization or even some improvement in their visual acuity.
American Psychological Association (APA)
Seguin-Greenstein, Sophie& Lightman, Susan L.& Tomkins, Oren. 2016. A Meta-Analysis of Studies Evaluating Visual and Anatomical Outcomes in Patients with Treatment Resistant Neovascular Age-Related Macular Degeneration following Switching to Treatment with Aflibercept. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109951
Modern Language Association (MLA)
Seguin-Greenstein, Sophie…[et al.]. A Meta-Analysis of Studies Evaluating Visual and Anatomical Outcomes in Patients with Treatment Resistant Neovascular Age-Related Macular Degeneration following Switching to Treatment with Aflibercept. Journal of Ophthalmology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109951
American Medical Association (AMA)
Seguin-Greenstein, Sophie& Lightman, Susan L.& Tomkins, Oren. A Meta-Analysis of Studies Evaluating Visual and Anatomical Outcomes in Patients with Treatment Resistant Neovascular Age-Related Macular Degeneration following Switching to Treatment with Aflibercept. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109951