Intravitreal Ranibizumab Injection as an Adjuvant in the Treatment of Neovascular Glaucoma Accompanied by Vitreous Hemorrhage after Diabetic Vitrectomy
Joint Authors
Zhong, Yisheng
Shen, Xi
Chen, Yanwei
Wang, Yanuo
Yang, Lu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To determine the efficacy of intravitreal ranibizumab injection as adjuvant therapy in the treatment of neovascular glaucoma (NVG) accompanied by postvitrectomy diabetic vitreous hemorrhage (PDVH).
Methods.
Eighteen NVG patients (18 eyes) accompanied by PDVH were enrolled in this prospective, monocenter, 12-month, interventional case series.
The consecutive 18 patients with an IOP ≥ 25 mmHg despite being treated with the maximum medical therapy were treated with intravitreal ranibizumab injections.
Vitreous surgery or/with Ahmed valve implantation were indicated if no clinical improvement in vitreous haemorrhage and uncontrolled IOP was shown.
Results.
Ten patients got clear vitreous and controlled IOP only with 2.7±1.8 injections of ranibizumab without additional surgery.
Vitrectomy or/with Ahmed valve implantation was administered in the other 8 eyes due to uncontrolled VH and IOP.
At follow-up month 12, all the 18 eyes gained clear vitreous.
At month 12 BCVA improved significantly compared to baseline.
The baseline and follow-up at month 12 IOP/medication usage were 36.7±8.1 mmHg on 3.4±0.7 medications and 16.2±4.9 mmHg on 0.67±0.77 medications, respectively.
Conclusions.
The findings suggest that intravitreal ranibizumab injection as adjuvant therapy for treatment of NVG accompanied by PDVH may be safe and potentially effective.
This clinical trial is registered with NCT02647515.
American Psychological Association (APA)
Shen, Xi& Chen, Yanwei& Wang, Yanuo& Yang, Lu& Zhong, Yisheng. 2016. Intravitreal Ranibizumab Injection as an Adjuvant in the Treatment of Neovascular Glaucoma Accompanied by Vitreous Hemorrhage after Diabetic Vitrectomy. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109952
Modern Language Association (MLA)
Shen, Xi…[et al.]. Intravitreal Ranibizumab Injection as an Adjuvant in the Treatment of Neovascular Glaucoma Accompanied by Vitreous Hemorrhage after Diabetic Vitrectomy. Journal of Ophthalmology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1109952
American Medical Association (AMA)
Shen, Xi& Chen, Yanwei& Wang, Yanuo& Yang, Lu& Zhong, Yisheng. Intravitreal Ranibizumab Injection as an Adjuvant in the Treatment of Neovascular Glaucoma Accompanied by Vitreous Hemorrhage after Diabetic Vitrectomy. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109952